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Existing sample-based methods, like influence functions and representer points, measure the importance of a training point by approximating the effect of its removal from training. As such, they are skewed towards outliers and points that are very close to the decision boundaries. The explanations provided by these methods are often static and not specific enough for different test points. In this paper, we propose a method to generate an explanation in the form of support spectrums which are based on two main ideas: the support sets and a global-to-local importance measure. The support set is the set of training points, in the predicted class, that ``lie in between'' the test point and training points in the other classes. They indicate how well the test point can be distinguished from the points not in the predicted class. The global-to-local importance measure is obtained by decoupling existing methods into the global and local components which are then used to select the points in the support set. Using this method, we are able to generate explanations that are tailored to specific test points. In the experiments, we show the effectiveness of the method in image classification and text generation tasks.

In this study, we generate and maintain a database of 10 million virtual lipids through METiS's in-house de novo lipid generation algorithms and lipid virtual screening techniques. These virtual lipids serve as a corpus for pre-training, lipid representation learning, and downstream task knowledge transfer, culminating in state-of-the-art LNP property prediction performance. We propose LipidBERT, a BERT-like model pre-trained with the Masked Language Model (MLM) and various secondary tasks. Additionally, we compare the performance of embeddings generated by LipidBERT and PhatGPT, our GPT-like lipid generation model, on downstream tasks. The proposed bilingual LipidBERT model operates in two languages: the language of ionizable lipid pre-training, using in-house dry-lab lipid structures, and the language of LNP fine-tuning, utilizing in-house LNP wet-lab data. This dual capability positions LipidBERT as a key AI-based filter for future screening tasks, including new versions of METiS de novo lipid libraries and, more importantly, candidates for in vivo testing for orgran-targeting LNPs. To the best of our knowledge, this is the first successful demonstration of the capability of a pre-trained language model on virtual lipids and its effectiveness in downstream tasks using web-lab data. This work showcases the clever utilization of METiS's in-house de novo lipid library as well as the power of dry-wet lab integration.

The recent explosion of attention to AI is arguably one of the biggest in the technology's media coverage. To investigate the effects it has on the discourse, we perform a mixed-method frame semantics-based analysis on a dataset of more than 49,000 sentences collected from 5846 news articles that mention AI. The dataset covers the twelve-month period centred around the launch of OpenAI's chatbot ChatGPT and is collected from the most visited open-access English-language news publishers. Our findings indicate that during the half year succeeding the launch, media attention rose tenfold$\unicode{x2014}$from already historically high levels. During this period, discourse has become increasingly centred around experts and political leaders, and AI has become more closely associated with dangers and risks. A deeper review of the data also suggests a qualitative shift in the types of threat AI is thought to represent, as well as the anthropomorphic qualities ascribed to it.

Recent dialogue systems rely on turn-based spoken interactions, requiring accurate Automatic Speech Recognition (ASR). Errors in ASR can significantly impact downstream dialogue tasks. To address this, using dialogue context from user and agent interactions for transcribing subsequent utterances has been proposed. This method incorporates the transcription of the user's speech and the agent's response as model input, using the accumulated context generated by each turn. However, this context is susceptible to ASR errors because it is generated by the ASR model in an auto-regressive fashion. Such noisy context can further degrade the benefits of context input, resulting in suboptimal ASR performance. In this paper, we introduce Context Noise Representation Learning (CNRL) to enhance robustness against noisy context, ultimately improving dialogue speech recognition accuracy. To maximize the advantage of context awareness, our approach includes decoder pre-training using text-based dialogue data and noise representation learning for a context encoder. Based on the evaluation of speech dialogues, our method shows superior results compared to baselines. Furthermore, the strength of our approach is highlighted in noisy environments where user speech is barely audible due to real-world noise, relying on contextual information to transcribe the input accurately.

Test-Time Adaptation (TTA) has emerged as a crucial solution to the domain shift challenge, wherein the target environment diverges from the original training environment. A prime exemplification is TTA for Automatic Speech Recognition (ASR), which enhances model performance by leveraging output prediction entropy minimization as a self-supervision signal. However, a key limitation of this self-supervision lies in its primary focus on acoustic features, with minimal attention to the linguistic properties of the input. To address this gap, we propose Language Informed Test-Time Adaptation (LI-TTA), which incorporates linguistic insights during TTA for ASR. LI-TTA integrates corrections from an external language model to merge linguistic with acoustic information by minimizing the CTC loss from the correction alongside the standard TTA loss. With extensive experiments, we show that LI-TTA effectively improves the performance of TTA for ASR in various distribution shift situations.

Previous studies reveal that Electronic Health Records (EHR), which have been widely adopted in the U.S. to allow patients to access their personal medical information, do not have high readability to patients due to the prevalence of medical jargon. Tailoring medical notes to individual comprehension by identifying jargon that is difficult for each person will enhance the utility of generative models. We present the first quantitative analysis to measure the impact of role-playing in LLM in medical term extraction. By comparing the results of Mechanical Turk workers over 20 sentences, our study demonstrates that LLM role-playing improves F1 scores in 95% of cases across 14 different socio-demographic backgrounds. Furthermore, applying role-playing with in-context learning outperformed the previous state-of-the-art models. Our research showed that ChatGPT can improve traditional medical term extraction systems by utilizing role-play to deliver personalized patient education, a potential that previous models had not achieved.

Whisper and other large-scale automatic speech recognition models have made significant progress in performance. However, their performance on many low-resource languages, such as Kazakh, is not satisfactory. It is worth researching how to utilize low-cost data to improve the performance of Whisper on under-represented languages. In this study, we utilized easily accessible unpaired speech and text data and combined the language model GPT with Whisper on Kazakh. We implemented end of transcript (EOT) judgment modification and hallucination penalty to improve the performance of speech recognition. Further, we employed the decoding average token log probability as a criterion to select samples from unlabeled speech data and used pseudo-labeled data to fine-tune the model to further improve its performance. Ultimately, we achieved more than 10\% absolute WER reduction in multiple experiments, and the whole process has the potential to be generalized to other under-represented languages.

Unified graph representation learning aims to produce node embeddings, which can be applied to multiple downstream applications. However, existing studies based on graph neural networks and language models either suffer from the limitations of numerous training needed toward specific downstream predictions or have shallow semantic features. In this work, we propose a novel Path-LLM model to learn unified graph representation, which leverages a powerful large language model (LLM) to incorporate our proposed path features. Our Path-LLM framework consists of several well-designed techniques. First, we develop a new mechanism of long-to-short shortest path (L2SP) selection, which covers essential connections between different dense groups. An in-depth comparison of different path selection plans is offered to illustrate the strength of our designed L2SP. Then, we design path textualization to obtain L2SP-based training texts. Next, we feed the texts into a self-supervised LLM training process to learn embeddings. Extensive experiments on benchmarks validate the superiority of Path-LLM against the state-of-the-art WalkLM method on two classical graph learning tasks (node classification and link prediction) and one NP-hard graph query processing task (keyword search), meanwhile saving more than 90% of training paths.

At the intersection of creative text generation and literary theory, this study explores the role of literary metaphor and its capacity to generate a range of meanings. In this regard, literary metaphor is vital to the development of any particular language. To investigate whether the inclusion of original figurative language improves textual quality, we trained an LSTM-based language model in Afrikaans. The network produces phrases containing compellingly novel figures of speech. Specifically, the emphasis falls on how AI might be utilised as a defamiliarisation technique, which disrupts expected uses of language to augment poetic expression. Providing a literary perspective on text generation, the paper raises thought-provoking questions on aesthetic value, interpretation and evaluation.

State-of-the-art medical multi-modal large language models (med-MLLM), like LLaVA-Med or BioMedGPT, leverage instruction-following data in pre-training. However, those models primarily focus on scaling the model size and data volume to boost performance while mainly relying on the autoregressive learning objectives. Surprisingly, we reveal that such learning schemes might result in a weak alignment between vision and language modalities, making these models highly reliant on extensive pre-training datasets - a significant challenge in medical domains due to the expensive and time-consuming nature of curating high-quality instruction-following instances. We address this with LoGra-Med, a new multi-graph alignment algorithm that enforces triplet correlations across image modalities, conversation-based descriptions, and extended captions. This helps the model capture contextual meaning, handle linguistic variability, and build cross-modal associations between visuals and text. To scale our approach, we designed an efficient end-to-end learning scheme using black-box gradient estimation, enabling faster LLaMa 7B training. Our results show LoGra-Med matches LLAVA-Med performance on 600K image-text pairs for Medical VQA and significantly outperforms it when trained on 10% of the data. For example, on VQA-RAD, we exceed LLAVA-Med by 20.13% and nearly match the 100% pre-training score (72.52% vs. 72.64%). We also surpass SOTA methods like BiomedGPT on visual chatbots and RadFM on zero-shot image classification with VQA, highlighting the effectiveness of multi-graph alignment.

Recent advancements in large language model (LLM)-powered agents have shown that collective intelligence can significantly outperform individual capabilities, largely attributed to the meticulously designed inter-agent communication topologies. Though impressive in performance, existing multi-agent pipelines inherently introduce substantial token overhead, as well as increased economic costs, which pose challenges for their large-scale deployments. In response to this challenge, we propose an economical, simple, and robust multi-agent communication framework, termed $\texttt{AgentPrune}$, which can seamlessly integrate into mainstream multi-agent systems and prunes redundant or even malicious communication messages. Technically, $\texttt{AgentPrune}$ is the first to identify and formally define the \textit{communication redundancy} issue present in current LLM-based multi-agent pipelines, and efficiently performs one-shot pruning on the spatial-temporal message-passing graph, yielding a token-economic and high-performing communication topology. Extensive experiments across six benchmarks demonstrate that $\texttt{AgentPrune}$ \textbf{(I)} achieves comparable results as state-of-the-art topologies at merely $\$5.6$ cost compared to their $\$43.7$, \textbf{(II)} integrates seamlessly into existing multi-agent frameworks with $28.1\%\sim72.8\%\downarrow$ token reduction, and \textbf{(III)} successfully defend against two types of agent-based adversarial attacks with $3.5\%\sim10.8\%\uparrow$ performance boost.

Speaker verification system trained on one domain usually suffers performance degradation when applied to another domain. To address this challenge, researchers commonly use feature distribution matching-based methods in unsupervised domain adaptation scenarios where some unlabeled target domain data is available. However, these methods often have limited performance improvement and lack generalization in various mismatch situations. In this paper, we propose Prototype and Instance Contrastive Learning (PICL), a novel method for unsupervised domain adaptation in speaker verification through dual-level contrastive learning. For prototype contrastive learning, we generate pseudo labels via clustering to create dynamically updated prototype representations, aligning instances with their corresponding class or cluster prototypes. For instance contrastive learning, we minimize the distance between different views or augmentations of the same instance, ensuring robust and invariant representations resilient to variations like noise. This dual-level approach provides both high-level and low-level supervision, leading to improved generalization and robustness of the speaker verification model. Unlike previous studies that only evaluated mismatches in one situation, we have conducted relevant explorations on various datasets and achieved state-of-the-art performance currently, which also proves the generalization of our method.