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Here we show that a Large Language Model (LLM) can serve as a foundation model for a Chemical Language Model (CLM) which performs at or above the level of CLMs trained solely on chemical SMILES string data. Using supervised fine-tuning (SFT) and direct preference optimization (DPO) on the open-source Llama LLM, we demonstrate that we can train an LLM to respond to prompts such as generating molecules with properties of interest to drug development. This overall framework allows an LLM to not just be a chatbot client for chemistry and materials tasks, but can be adapted to speak more directly as a CLM which can generate molecules with user-specified properties.

Historic variations of spelling poses a challenge for full-text search or natural language processing on historical digitized texts. To minimize the gap between the historic orthography and contemporary spelling, usually an automatic orthographic normalization of the historical source material is pursued. This report proposes a normalization system for German literary texts from c. 1700-1900, trained on a parallel corpus. The proposed system makes use of a machine learning approach using Transformer language models, combining an encoder-decoder model to normalize individual word types, and a pre-trained causal language model to adjust these normalizations within their context. An extensive evaluation shows that the proposed system provides state-of-the-art accuracy, comparable with a much larger fully end-to-end sentence-based normalization system, fine-tuning a pre-trained Transformer large language model. However, the normalization of historical text remains a challenge due to difficulties for models to generalize, and the lack of extensive high-quality parallel data.

Domain adaptation is a widely used method in natural language processing (NLP) to improve the performance of a language model within a specific domain. This method is particularly common in the biomedical domain, which sees regular publication of numerous scientific articles. PubMed, a significant corpus of text, is frequently used in the biomedical domain. The primary objective of this study is to explore whether refining a pre-training dataset using specific quality metrics for scientific papers can enhance the performance of the resulting model. To accomplish this, we employ two straightforward journal impact metrics and conduct experiments by continually pre-training BERT on various subsets of the complete PubMed training set, we then evaluate the resulting models on biomedical language understanding tasks from the BLURB benchmark. Our results show that pruning using journal impact metrics is not efficient. But we also show that pre-training using fewer abstracts (but with the same number of training steps) does not necessarily decrease the resulting model's performance.

Wider access to therapeutic care is one of the biggest challenges in mental health treatment. Due to institutional barriers, some people seeking mental health support have turned to large language models (LLMs) for personalized therapy, even though these models are largely unsanctioned and untested. We investigate the potential and limitations of using LLMs as providers of evidence-based therapy by using mixed methods clinical metrics. Using HELPERT, a prompt run on a large language model using the same process and training as a comparative group of peer counselors, we replicated publicly accessible mental health conversations rooted in Cognitive Behavioral Therapy (CBT) to compare session dynamics and counselor's CBT-based behaviors between original peer support sessions and their reconstructed HELPERT sessions. Two licensed, CBT-trained clinical psychologists evaluated the sessions using the Cognitive Therapy Rating Scale and provided qualitative feedback. Our findings show that the peer sessions are characterized by empathy, small talk, therapeutic alliance, and shared experiences but often exhibit therapist drift. Conversely, HELPERT reconstructed sessions exhibit minimal therapist drift and higher adherence to CBT methods but display a lack of collaboration, empathy, and cultural understanding. Through CTRS ratings and psychologists' feedback, we highlight the importance of human-AI collaboration for scalable mental health. Our work outlines the ethical implication of imparting human-like subjective qualities to LLMs in therapeutic settings, particularly the risk of deceptive empathy, which may lead to unrealistic patient expectations and potential harm.

Due to the inherent difficulty in modeling phonetic similarities across different languages, code-switching speech recognition presents a formidable challenge. This study proposes a Collaborative-MoE, a Mixture of Experts (MoE) model that leverages a collaborative mechanism among expert groups. Initially, a preceding routing network explicitly learns Language Identification (LID) tasks and selects experts based on acquired LID weights. This process ensures robust routing information to the MoE layer, mitigating interference from diverse language domains on expert network parameter updates. The LID weights are also employed to facilitate inter-group collaboration, enabling the integration of language-specific representations. Furthermore, within each language expert group, a gating network operates unsupervised to foster collaboration on attributes beyond language. Extensive experiments demonstrate the efficacy of our approach, achieving significant performance enhancements compared to alternative methods. Importantly, our method preserves the efficient inference capabilities characteristic of MoE models without necessitating additional pre-training.

Werewolf is an incomplete information game, which has several challenges when creating a computer agent as a player given the lack of understanding of the situation and individuality of utterance (e.g., computer agents are not capable of characterful utterance or situational lying). We propose a werewolf agent that solves some of those difficulties by combining a Large Language Model (LLM) and a rule-based algorithm. In particular, our agent uses a rule-based algorithm to select an output either from an LLM or a template prepared beforehand based on the results of analyzing conversation history using an LLM. It allows the agent to refute in specific situations, identify when to end the conversation, and behave with persona. This approach mitigated conversational inconsistencies and facilitated logical utterance as a result. We also conducted a qualitative evaluation, which resulted in our agent being perceived as more human-like compared to an unmodified LLM. The agent is freely available for contributing to advance the research in the field of Werewolf game.

This paper presents an in-depth analysis of the latency characteristics observed in simultaneous speech-to-speech model's performance, particularly focusing on hallucination-induced latency spikes. By systematically experimenting with various input parameters and conditions, we propose methods to minimize latency spikes and improve overall performance. The findings suggest that a combination of careful input management and strategic parameter adjustments can significantly enhance speech-to-speech model's latency behavior.

The evolving speech processing landscape is increasingly focused on complex scenarios like meetings or cocktail parties with multiple simultaneous speakers and far-field conditions. Existing methodologies for addressing these challenges fall into two categories: multi-channel and single-channel solutions. Single-channel approaches, notable for their generality and convenience, do not require specific information about microphone arrays. This paper presents a large-scale far-field overlapping speech dataset, crafted to advance research in speech separation, recognition, and speaker diarization. This dataset is a critical resource for decoding ``Who said What and When'' in multi-talker, reverberant environments, a daunting challenge in the field. Additionally, we introduce a pipeline system encompassing speech separation, recognition, and diarization as a foundational benchmark. Evaluations on the WHAMR! dataset validate the broad applicability of the proposed data.

Concept activation vector (CAV) has attracted broad research interest in explainable AI, by elegantly attributing model predictions to specific concepts. However, the training of CAV often necessitates a large number of high-quality images, which are expensive to curate and thus limited to a predefined set of concepts. To address this issue, we propose Language-Guided CAV (LG-CAV) to harness the abundant concept knowledge within the certain pre-trained vision-language models (e.g., CLIP). This method allows training any CAV without labeled data, by utilizing the corresponding concept descriptions as guidance. To bridge the gap between vision-language model and the target model, we calculate the activation values of concept descriptions on a common pool of images (probe images) with vision-language model and utilize them as language guidance to train the LG-CAV. Furthermore, after training high-quality LG-CAVs related to all the predicted classes in the target model, we propose the activation sample reweighting (ASR), serving as a model correction technique, to improve the performance of the target model in return. Experiments on four datasets across nine architectures demonstrate that LG-CAV achieves significantly superior quality to previous CAV methods given any concept, and our model correction method achieves state-of-the-art performance compared to existing concept-based methods. Our code is available at https://github.com/hqhQAQ/LG-CAV.

Human sensing, which employs various sensors and advanced deep learning technologies to accurately capture and interpret human body information, has significantly impacted fields like public security and robotics. However, current human sensing primarily depends on modalities such as cameras and LiDAR, each of which has its own strengths and limitations. Furthermore, existing multi-modal fusion solutions are typically designed for fixed modality combinations, requiring extensive retraining when modalities are added or removed for diverse scenarios. In this paper, we propose a modality-invariant foundation model for all modalities, X-Fi, to address this issue. X-Fi enables the independent or combinatory use of sensor modalities without additional training by utilizing a transformer structure to accommodate variable input sizes and incorporating a novel "X-fusion" mechanism to preserve modality-specific features during multimodal integration. This approach not only enhances adaptability but also facilitates the learning of complementary features across modalities. Extensive experiments conducted on the MM-Fi and XRF55 datasets, employing six distinct modalities, demonstrate that X-Fi achieves state-of-the-art performance in human pose estimation (HPE) and human activity recognition (HAR) tasks. The findings indicate that our proposed model can efficiently support a wide range of human sensing applications, ultimately contributing to the evolution of scalable, multimodal sensing technologies.

Recent advancements in multi-modal large language models have propelled the development of joint probabilistic models capable of both image understanding and generation. However, we have identified that recent methods inevitably suffer from loss of image information during understanding task, due to either image discretization or diffusion denoising steps. To address this issue, we propose a novel Multi-Modal Auto-Regressive (MMAR) probabilistic modeling framework. Unlike discretization line of method, MMAR takes in continuous-valued image tokens to avoid information loss. Differing from diffusion-based approaches, we disentangle the diffusion process from auto-regressive backbone model by employing a light-weight diffusion head on top each auto-regressed image patch embedding. In this way, when the model transits from image generation to understanding through text generation, the backbone model's hidden representation of the image is not limited to the last denoising step. To successfully train our method, we also propose a theoretically proven technique that addresses the numerical stability issue and a training strategy that balances the generation and understanding task goals. Through extensive evaluations on 18 image understanding benchmarks, MMAR demonstrates much more superior performance than other joint multi-modal models, matching the method that employs pretrained CLIP vision encoder, meanwhile being able to generate high quality images at the same time. We also showed that our method is scalable with larger data and model size.

Recently, diffusion models have achieved great success in mono-channel audio generation. However, when it comes to stereo audio generation, the soundscapes often have a complex scene of multiple objects and directions. Controlling stereo audio with spatial contexts remains challenging due to high data costs and unstable generative models. To the best of our knowledge, this work represents the first attempt to address these issues. We first construct a large-scale, simulation-based, and GPT-assisted dataset, BEWO-1M, with abundant soundscapes and descriptions even including moving and multiple sources. Beyond text modality, we have also acquired a set of images and rationally paired stereo audios through retrieval to advance multimodal generation. Existing audio generation models tend to generate rather random and indistinct spatial audio. To provide accurate guidance for latent diffusion models, we introduce the SpatialSonic model utilizing spatial-aware encoders and azimuth state matrices to reveal reasonable spatial guidance. By leveraging spatial guidance, our unified model not only achieves the objective of generating immersive and controllable spatial audio from text and image but also enables interactive audio generation during inference. Finally, under fair settings, we conduct subjective and objective evaluations on simulated and real-world data to compare our approach with prevailing methods. The results demonstrate the effectiveness of our method, highlighting its capability to generate spatial audio that adheres to physical rules.